Related Experiment Video
Updated: Aug 1, 2026
06:17
Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
The alteration of osteoclast morphology by diphosphonates in bone organ culture
Calcified Tissue Research
|April 13, 1976
Abstract:
Two diphosphonates alter the morphology of the osteoclast, as they inhibit the calcium45 release from bones stimulated to resorb by lipopolysaccharide. Disodium dichloromethylene diphosphonate was more potent than disodium ethane-1-hydroxy-1, 1-diphosphonate in both inhibiting 45calium release and altering osteoclast morphology. Alteration in the morphology of osteoclasts is associated with little or no change in the morphology of the surrounding non-osteoclast cells. These results indicate a specific morphological effect of diphosphonates on osteoclasts.
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