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Formal catalytic asymmetric total synthesis of fostriecin
Kunihiko Fujii1, Keisuke Maki, Motomu Kanai
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Organic Letters
|February 28, 2003
Abstract:
The common synthetic intermediate of a potent and promising anticancer agent, fostriecin, was synthesized using a unique method that combines four catalytic asymmetric reactions as shown above.