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Efficient synthesis of macrocyclic paracyclophanes by ring-closing metathesis dimerization and trimerization
1Department of Chemistry, Yonsei University, Seoul, 120-749, Korea. jstae@yonsei.ac.kr
Organic Letters
|February 28, 2003
Abstract:
Ring-closing metathesis reactions of para-disubstituted aromatic substrates produced macrocyclic [n.n]-, and [n.n.n]paracyclophanes efficiently through dimerization and trimerization reactions. Sufficiently long alkyl chains allowed direct monocyclizations to yield [n]paracyclophanes. A small library of paracyclophanes were generated by the combinatorial cross-metathesis approach.