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Total synthesis of (-)-aspidospermine via diastereoselective ring-closing olefin metathesis
Yu-Ichi Fukuda1, Mitsuru Shindo, Kozo Shishido
1Institute for Medicinal Resources, University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan.
Organic Letters
|February 28, 2003
Abstract:
An enantiocontrolled total synthesis of (-)-aspidospermine has been achieved. The key element of the strategy is the diastereoselective construction of the quaternary stereogenic center employing 1,4-asymmetric induction during the ring-closing olefin metathesis.