Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Ability of Activity and Cognition in Old Mice to Predict Age of Death.

Aging and disease·2025
Same author

Mitochondrial Ca<sup>2+</sup> uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain.

The Journal of physiology·2025
Same author

Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023
Same author

Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain.

GeroScience·2023
Same author

Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive <i>Listeria monocytogenes</i> infection.

Frontiers in immunology·2023
Same author

Cognitive heterogeneity reveals molecular signatures of age-related impairment.

PNAS nexus·2023
Same journal

Lactylation in the Ageing Nervous System: Epi-metabolic Regulation, Disease Mechanisms, and Translational Challenges.

Ageing research reviews·2026
Same journal

AI-Driven Advances in Vascular Aging Research: From Mechanisms to Precision Medicine.

Ageing research reviews·2026
Same journal

Brain Health Across the Lifespan and the Impact of Nutrition, Exercise, Microbiota, and Sleep.

Ageing research reviews·2026
Same journal

Assessing the relationships between frailty, sarcopenia and Alzheimer's disease biomarkers: a scoping review.

Ageing research reviews·2026
Same journal

Restoring the balance: Resistance exercise-induced insulin-like growth factor-1 restores PI3K/Akt and MAPK/ERK cross-talk to ameliorate Alzheimer's disease.

Ageing research reviews·2026
Same journal

From organ age gaps to precision geromedicine: multi-omic and imaging frameworks for heterogeneous biological aging.

Ageing research reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

Microvascular plasticity in aging.

David R Riddle1, William E Sonntag, Robin J Lichtenwalner

  • 1Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1010, USA. driddle@wfubmc.edu

Ageing Research Reviews
|February 28, 2003
PubMed
Summary
This summary is machine-generated.

Aging reduces brain plasticity and cerebral blood flow by altering microvasculature, impacting cognitive function. This decline affects neuronal signaling and neurogenesis, highlighting the critical role of vascular health in brain aging.

More Related Videos

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jun 19, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Area of Science:

  • Neurobiology
  • Gerontology
  • Vascular Biology

Background:

  • Aging-related cognitive decline is a major neurobiological challenge.
  • Neuronal plasticity decreases with senescence, despite minimal neuron loss.
  • Cerebral microvasculature changes with age, affecting brain function.

Purpose of the Study:

  • To investigate the impact of aging on brain microvasculature and its functional consequences.
  • To understand how microvascular changes affect cerebral blood flow and neuronal plasticity.
  • To explore the link between microvascular plasticity and neurogenesis during aging.

Main Methods:

  • Quantitative analysis of neuronal and synaptic changes.
  • Assessment of microvascular structure and density in aging brains.
  • Measurement of cerebral blood flow (CBF) and its regulation.
  • Investigation of neurogenesis and capillary growth coordination.

Main Results:

  • Aging leads to microvascular rarefaction and structural changes in the brain.
  • Reduced cerebral blood flow (CBF) impairs metabolic support for neural signaling.
  • Microvascular plasticity diminishes with age, hindering response to metabolic demand.
  • Loss of microvascular plasticity is linked to reduced neurogenesis.

Conclusions:

  • Aging-induced microvascular alterations significantly contribute to cognitive decline.
  • Impaired cerebral blood flow and reduced vascular plasticity are key factors in brain aging.
  • Maintaining vascular health is crucial for preserving neuronal function and neurogenesis throughout life.