Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

114
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
114
Aging01:26

Aging

54
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
54
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

491
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
491
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

439
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
439
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.

Nutrients·2026
Same author

Training status augments mechanisms of rapid‑onset vasodilation in healthy young adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Spatial transcriptome mapping identifies <i>Ppara-Anxa2</i> cross-talk in microplastic-induced hepatotoxicity.

Science advances·2026
Same author

Focused ultrasound opens the blood-brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle.

GeroScience·2026
Same author

Dietary Polyphenols in Brain Aging: Molecular Mechanisms and Implications for Neurodegeneration.

Nutrients·2026
Same journal

Multi-tissue Metabolic GWAS and Drought-Responsive Multi-omics Reveal the Genetic Basis of the Quinoa Metabolome.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Bioinspired Multifunctional Flexible C-SiC Fibrous Aerogel for Superior Electromagnetic Interference Shielding Under Extreme Environments.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

From Chatbots to Co-Scientists: The Impact of Knowledge-Generating AI (AI 4.0) on Healthcare and Research.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Cobalt Single-Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Ultrafast Optoacoustics Reveals Intricate 3D Anisotropic Elasticity in Nanocrystalline Membranes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.2K

Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related

Peter Mukli1,2,3,4, Camila B Pinto1,2, Cameron D Owens1,2

  • 1Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 29, 2023
PubMed
Summary
This summary is machine-generated.

Older adults show impaired neurovascular coupling (NVC) and increased brain network connectivity, which predicts cognitive decline in working memory tasks. These changes suggest compensatory mechanisms for age-related cognitive dysfunction.

Keywords:
agingcognitive declinefunctional connectivityfunctional near-infrared spectroscopyneurovascular coupling

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

7.9K

Related Experiment Videos

Last Updated: Jul 6, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.2K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

7.9K

Area of Science:

  • Neuroscience
  • Cerebrovascular Biology
  • Cognitive Aging Research

Background:

  • Age-related cognitive decline is linked to cerebrovascular dysfunction.
  • Neurovascular coupling (NVC) and brain network function are critical for cognitive performance.
  • Understanding these relationships is key to addressing cognitive impairment in aging.

Purpose of the Study:

  • To investigate if impaired NVC and brain network function predict cognitive dysfunction in older adults.
  • To compare NVC and functional connectivity (FC) between young and aged individuals during a working memory task.

Main Methods:

  • Assessed cerebrovascular and working memory function in healthy young and aged participants.
  • Recorded frontal cortex oxy- and deoxyhemoglobin changes using functional near-infrared spectroscopy (fNIRS) during an n-back task.
  • Analyzed NVC responses and functional connectivity (FC) patterns.

Main Results:

  • Aged participants exhibited significantly impaired NVC during the 2-back task.
  • Frontal networks in aged individuals showed higher local and global connection strength and dynamic FC.
  • Both impaired NVC and increased FC correlated with reduced accuracy in the 2-back task.

Conclusions:

  • Task-related brain states in older adults may necessitate stronger functional connections.
  • These enhanced connections might compensate for attenuated NVC responses during working memory tasks.
  • Findings highlight the interplay between cerebrovascular health, brain networks, and cognitive function in aging.