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Updated: Jun 19, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
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Spatial transcriptome mapping identifies Ppara-Anxa2 cross-talk in microplastic-induced hepatotoxicity.

Woncheol Jung1, Hassan Abushukair1, Nikhil Y Patil2,3

  • 1Department of Oncology Science, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, OK, USA.

Science Advances
|June 17, 2026
PubMed

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Summary

Polyethylene microplastics cause liver dysfunction and alter gene expression in mice. Spatial transcriptomics reveals inflammatory hotspots and identifies nuclear receptor Ppara as a key regulator of damage response genes.

Area of Science:

  • Environmental Health
  • Toxicology
  • Molecular Biology

Background:

  • Microplastics (MPs) are a growing global health concern, linked to chronic diseases.
  • The liver is vulnerable to MP exposure, but mechanisms of polyethylene (PE) impact are unclear.

Purpose of the Study:

  • To investigate hepatic responses to polyethylene (PE) microplastic exposure.
  • To elucidate the molecular mechanisms of PE-induced liver dysfunction using advanced transcriptomic analysis.

Main Methods:

  • Combined bulk and spatial transcriptomics in mice exposed to PE.
  • Analysis of transcriptional alterations in standard and MASH-inducing diets.
  • Identification of key nuclear receptors and their regulatory targets.

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Main Results:

  • PE exposure caused hepatic dysfunction and distinct transcriptional changes.
  • Spatial transcriptomics revealed inflammatory hotspots and cell type heterogeneity.
  • Nuclear receptor signaling, particularly Ppara, emerged as a key regulatory axis.

Conclusions:

  • PE microplastics disrupt hepatic homeostasis and tissue organization.
  • Spatial transcriptomics is valuable for understanding environmental impacts on liver pathophysiology.
  • Ppara and its regulation of Anxa2 offer potential therapeutic targets for MP-induced liver damage.