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[Heart rate variability in patients with hypertrophic cardiomyopathy and in their close relatives]

Maciej Sosnowski1, Krystyna Kozakiewicz, Barbara Korzeniowska

  • 1III Katedry i Kliniki Kardiologii, Slaskiej Akademii Medycznej w Katowicach.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|February 28, 2003
PubMed

Insights

Reduced heart rate variability (HRV) is common in hypertrophic cardiomyopathy (HCM) patients and their relatives. This study found lower HRV in HCM patients and a significant number of their family members, suggesting a familial link.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Function
  • Genetics

Context:

  • Conflicting results exist regarding heart rate variability (HRV) in hypertrophic cardiomyopathy (HCM).
  • Short-term HRV was evaluated in HCM patients and their first-degree relatives.
  • This study investigated familial patterns of HRV in HCM.

Purpose:

  • To assess short-term HRV in patients with diagnosed HCM and their close relatives.
  • To identify potential familial links in HRV abnormalities associated with HCM.
  • To compare HRV parameters between HCM patients, their relatives, and healthy controls.

Summary:

  • Patients with HCM and their relatives exhibited significantly shorter mean RR intervals and faster respiratory rates compared to controls.
  • Reduced HRV measures (SDRR, lnHF, lnLF) were observed in the HCM group compared to controls.
  • Family members also showed reduced SDRR and lnHF, with HRV reduction more pronounced in individuals under 30 years old.

Impact:

  • Reduced HRV is prevalent not only in diagnosed HCM patients but also in a substantial proportion of their relatives.
  • Findings suggest that HRV analysis can identify at-risk individuals within HCM families.
  • This research contributes to understanding the familial component of autonomic dysfunction in HCM.

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