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Pathophysiology of anorexia.

John E Morley1

  • 1Division of Geriatric Medicine, St. Louis University School of Medicine, 1402 South Grand Boulevard, M238, St. Louis, MO 63104, USA. morley@slu.edu

Clinics in Geriatric Medicine
|March 1, 2003
PubMed
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Physiologic anorexia of aging causes weight loss and protein-energy malnutrition in older adults. Many contributing factors are treatable, potentially reversing malnutrition.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Internal Medicine

Background:

  • Aging leads to a natural decrease in appetite, known as the physiologic anorexia of aging.
  • This decline in food intake can result in significant weight loss in older individuals.
  • Protein-energy malnutrition is a common consequence of anorexia of aging in the elderly.

Purpose of the Study:

  • To review the physiological factors contributing to anorexia in older adults.
  • To examine the pathological processes that cause protein-energy malnutrition in the elderly.
  • To identify potential treatment avenues for malnutrition in aging populations.

Main Methods:

  • Literature review of physiological changes associated with aging and appetite.
  • Analysis of social, psychological, disease-related, and medication-related factors impacting food intake.

Related Experiment Videos

  • Examination of pathological mechanisms leading to protein-energy malnutrition.

    • Main Results:

    • Physiologic anorexia of aging is a key factor in reduced food intake.
    • Social, psychological, medical conditions, and medications can worsen anorexia and weight loss.
    • Many factors contributing to malnutrition are treatable, offering potential for reversal.

    Conclusions:

    • Anorexia of aging and associated malnutrition are significant concerns in older populations.
    • Understanding the multifactorial causes is crucial for effective intervention.
    • Treatment of contributing factors can reverse malnutrition and improve health outcomes.