Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Orexigenic and anabolic agents.

John E Morley1

  • 1Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard M238, Saint Louis, MO 63104, USA. morley@slu.edu

Clinics in Geriatric Medicine
|March 1, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 mice.

PloS one·2025
Same author

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).

The journal of nutrition, health & aging·2025
Same author

Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes.

Nutrition (Burbank, Los Angeles County, Calif.)·2024
Same author

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.

The Journal of biological chemistry·2023
Same author

Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance.

npj aging·2023
Same author

Anorexia of aging: An international assessment of healthcare providers' knowledge and practice gaps.

Journal of cachexia, sarcopenia and muscle·2023
Same journal

Cardiovascular Prevention in Older Adults: From Estimation to Treatment.

Clinics in geriatric medicine·2026
Same journal

Preventive Cardiology for the Clinically Complex Older Adult.

Clinics in geriatric medicine·2026
Same journal

A Preventive Neurology Perspective on Promoting Brain Health and Preventing Cardiovascular Disease.

Clinics in geriatric medicine·2026
Same journal

Secondary Prevention in Older Adults: Putting It All Together.

Clinics in geriatric medicine·2026
Same journal

Primary Prevention in Older Adults: Putting It All Together.

Clinics in geriatric medicine·2026
Same journal

Managing Bleeding Risk in Older Adults: Antithrombotics and Anticoagulants.

Clinics in geriatric medicine·2026
See all related articles

Megestrol acetate and dronabinol are effective anorectic agents for weight loss. Dronabinol is recommended for most patients, while megestrol acetate has specific indications and contraindications.

Area of Science:

  • Geriatrics
  • Pharmacology
  • Internal Medicine

Background:

  • Anorexia and weight loss are significant causes of morbidity and mortality.
  • Current treatments include megestrol acetate and dronabinol.

Purpose of the Study:

  • Compare the efficacy and appropriate use of megestrol acetate and dronabinol.
  • Provide guidance on managing anorexia and weight loss in older adults.

Main Methods:

  • Comparative analysis of megestrol acetate and dronabinol.
  • Review of current treatment guidelines and clinical considerations.

Main Results:

  • Megestrol acetate: suitable for excess cytokine production, requires testosterone in men, avoid in bed-bound patients due to DVT risk.

Related Experiment Videos

  • Dronabinol: recommended for most patients, start low dose (2.5mg) and increase if needed, suitable for end-of-life anorexia.
  • Mirtazapine for depression with anorexia; taste enhancers for taste disturbances; testosterone replacement for older men with low levels.

    • Conclusions:

    • Dronabinol is a generally preferred anorectic agent.
    • Megestrol acetate has specific indications and contraindications.
    • Individualized treatment approaches, including hormonal therapy and supportive measures, are crucial for managing anorexia and weight loss.