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Two novel cytotoxic cyclodepsipeptides from a mycoparasitic Cladobotryum sp
Yunjiang Feng1, John W Blunt, Anthony L J Cole
1Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
The Journal of Organic Chemistry
|March 1, 2003
Abstract:
Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.