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Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate
Phil B Alper1, KhanhLinh T Nguyen
1The Genomics Institute of the Novartis Foundation, 10675 John Jay Hopkins, San Diego, California 92121-1125, USA. palper@gnf.org
The Journal of Organic Chemistry
|March 1, 2003
Abstract:
A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the "diversity generating elements" of this important pharmacophore.