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A pilot study of donepezil for memory problems in epilepsy.
R S Fisher1, J J Bortz, D E Blum
1Stanford Comprehensive Epilepsy Center, Stanford, California.
Epilepsy & Behavior : E&B
|March 1, 2003
Summary
Donepezil, an anticholinesterase inhibitor, showed potential for improving memory in epilepsy patients. However, careful monitoring is needed due to possible seizure exacerbation and side effects.
Area of Science:
- Neurology
- Pharmacology
Background:
- Memory deficits are common in epilepsy.
- Anticholinesterase inhibitors like donepezil may offer therapeutic benefits.
Purpose of the Study:
- To investigate the efficacy and safety of donepezil for memory problems in epilepsy patients.
Main Methods:
- A 3-month, open-label pilot study.
- Involved 18 epilepsy patients receiving 5-10 mg of donepezil daily.
- Memory assessed using the Buschke Selective Reminding Test.
Main Results:
- Improved word recall was observed in patients taking donepezil (P=0.4).
- No significant changes in attention, cognitive flexibility, or quality of life.
- Seizure frequency did not significantly change, but two patients had increased seizures.
Conclusions:
- Donepezil may be a viable option for memory issues in epilepsy.
- Further research is warranted, with attention to potential seizure risks and side effects.