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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Risk factors for persistent abnormality on chest radiographs at 12-weeks post hospitalisation with PCR confirmed

T J M Wallis1,2, E Heiden3, J Horno3

  • 1Department of Respiratory Medicine and Southampton NIHR Biomedical Research Centre, University Hospital Southampton and School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. timothy.wallis@soton.ac.uk.

Respiratory Research
|May 22, 2021
PubMed

Insights

Persistent chest X-ray abnormalities after COVID-19 hospitalization were common. Key risk factors included longer hospital stays, obesity, and smoking, highlighting the need for further research into long-term respiratory effects.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Radiology

Background:

  • Long-term consequences of COVID-19, including pulmonary fibrosis, are not fully understood.
  • Assessing temporal changes in chest X-ray (CXR) infiltrates post-COVID-19 hospitalization is crucial.

Purpose of the Study:

  • To evaluate the changes in CXR infiltrates 12 weeks after hospital admission for COVID-19.
  • To identify risk factors associated with persistent radiographic abnormalities.

Main Methods:

  • Prospective cohort study of 101 patients hospitalized with COVID-19.
  • CXR scoring for pulmonary infiltrates at baseline and 12-week follow-up.
  • Multivariate analysis to identify independent risk factors for persistent abnormalities.

Main Results:

  • 32% of patients exhibited persistent CXR abnormalities at 12 weeks.
  • Independent risk factors for persistent abnormalities included longer length of stay (LOS), obesity, and smoking status.
  • Elevated serum lactate dehydrogenase (LDH) levels were associated with persistent CXR abnormalities.

Conclusions:

  • Persistent CXR abnormalities are common 12 weeks post-COVID-19 hospitalization.
  • LOS, obesity, elevated LDH, and smoking status are significant risk factors.
  • Further prospective studies are needed to validate these findings.
Abstract

Keywords:
COVID-19Chest radiographFollow-up studyLDHSARS-CoV-2

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