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Updated: Jul 7, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Right and left ventricular volume characteristics in children with pulmonary stenosis and intact ventricular septum

M Nakazawa, R A Marks, J Isabel-Jones

    Circulation
    |May 1, 1976
    PubMed

    Insights

    In patients with isolated pulmonary stenosis (PS), right and left ventricular function are normal. However, PS with a right-to-left atrial shunt indicates depressed ventricular function, necessitating RV volume assessment for management.

    Area of Science:

    • Cardiology
    • Pediatric Cardiology
    • Echocardiography

    Background:

    • Pulmonary stenosis (PS) is a common congenital heart defect.
    • Assessing ventricular function is crucial for managing PS patients.
    • Distinguishing isolated PS from PS with shunts is important for treatment.

    Purpose of the Study:

    • To evaluate right ventricular (RV) and left ventricular (LV) volume variables in patients with PS.
    • To compare ventricular function in isolated PS versus PS with a right-to-left atrial shunt.
    • To determine the clinical utility of RV volume assessment in PS management.

    Main Methods:

    • Cardiac catheterization was performed on 27 patients with PS.
    • Patients were divided into isolated PS (group I) and PS with shunt (group II).
    • RV and LV volumes were calculated using Simpson's rule and area-length methods.

    Main Results:

    • In isolated PS, RV ejection fraction was normal, but RVEDV/LVEDV ratio was reduced.
    • RV end-diastolic volume decreased with age and obstruction severity in isolated PS.
    • In PS with shunt, RV and LV volumes showed depressed function, despite normal RV ejection fraction.

    Conclusions:

    • Ventricular function is generally normal in children with isolated PS.
    • RV volume assessment is not essential for managing isolated PS.
    • PS with a right-to-left atrial shunt shows signs of depressed ventricular function, making RV volume quantitation helpful for management.

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