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Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice
Tadamasa Terai1, Kanehiro Osakabe, Masaaki Katai
1Department of Applied Chemistry, Osaka Institute of Technology, Japan. tera@chem.oit.ac.jp
Chemical & Pharmaceutical Bulletin
|March 4, 2003
Abstract:
Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9beta-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II.