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Updated: May 5, 2026
10:59
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
Published on: May 19, 2014
17.8K
Does the ribosome translate cancer?
Davide Ruggero1, Pier Paolo Pandolfi
1Molecular Biology Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA.
Nature Reviews. Cancer
|March 4, 2003
Summary
Ribosome biogenesis and translation control are vital cellular processes. Dysregulation of protein synthesis machinery by tumor suppressors and proto-oncogenes may influence cancer susceptibility.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Ribosome biogenesis and translation are fundamental cellular processes.
- Tumor suppressors and proto-oncogenes can impact ribosome formation and translation factor activity.
- Disruptions in protein biosynthesis are linked to cell cycle and growth regulation.
Purpose of the Study:
- To investigate the role of tumor suppressors and proto-oncogenes in regulating protein synthesis.
- To explore the connection between altered protein biosynthesis and cancer susceptibility.
Main Methods:
- Analysis of tumor suppressor and proto-oncogene functions.
- Investigation of ribosome biogenesis and translation control mechanisms.
- Correlation studies between protein biosynthesis deregulation and cancer development.
Main Results:
- Identified several tumor suppressors and proto-oncogenes affecting ribosome biogenesis and translation.
- Demonstrated links between protein biosynthesis alterations, cell cycle, and growth regulation.
- Observed correlations between protein biosynthesis deregulation and cancer, but causality requires further establishment.
Conclusions:
- Tumor suppressors and proto-oncogenes may drive malignant progression by modulating protein synthesis.
- Further research is needed to confirm if altered protein biosynthesis directly increases cancer susceptibility and under which conditions.
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