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Cardiac contractility modulation with nonexcitatory electric signals improves left ventricular function in dogs with
Hideaki Morita1, George Suzuki, Walid Haddad
1Departments of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, Michigan 48202, USA.
Background:
Nonexcitatory electrical, signals termed cardiac contractility modulation (CCM) have been shown to improve contractile force of isolated papillary muscles. In this study, we examined the effects of CCM signal delivery on left ventricular function in dogs with chronic heart failure (HF).
Methods And Results:
Chronic HF (ejection fraction
Conclusion:
In dogs with HF, CCM signal delivery for 6 hours elicited marked improvement in LV function. This novel approach may represent a useful adjunctive therapy for the treatment of patients with HF.