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Toxicological studies on azapropazone.

R W Adrian, F S Walker, P R Noel

    Current Medical Research and Opinion
    |January 1, 1976
    PubMed
    Summary

    Azapropazone, an anti-inflammatory drug, showed gastrointestinal ulceration risk primarily in beagle dogs. Other species, including primates, exhibited a lack of significant toxicity, suggesting comparable safety to other anti-inflammatory agents.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Veterinary Medicine

    Background:

    • Azapropazone is a non-steroidal anti-inflammatory analgesic.
    • Understanding its toxicological profile across various species is crucial for safety assessment.

    Purpose of the Study:

    • To evaluate the toxicity of azapropazone in a wide range of animal models.
    • To identify potential target organs and species-specific sensitivities.

    Main Methods:

    • Acute and sub-chronic toxicity studies were conducted.
    • A diverse range of species were included: mice, rats, hamsters, guinea pigs, rabbits, cats, dogs, pigs, and non-human primates.
    • Dose ranges varied from acute single doses to 1-year treatment periods.

    Main Results:

    • Beagle dogs exhibited significant gastrointestinal ulceration.
    • Rats, mice, hamsters, guinea pigs, rabbits, cats, pigs, and all three primate species showed minimal gastrointestinal effects.
    • No adverse effects were observed in other body systems across species.
    • Azapropazone demonstrated no teratogenic, carcinogenic, or antimitotic activity.
    • No local tissue damage was reported.

    Conclusions:

    • Azapropazone's primary toxicity is gastrointestinal ulceration, notably in beagle dogs.
    • The compound appears safe for other body systems and is comparable to other anti-inflammatory drugs.
    • Species-specific toxicity, particularly in beagle dogs, should be considered in risk assessments.

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