Effect of partial ileal bypass on the lipid profile in the hyperlipedemic rabbits

The hypocholesterolemic effect of partial ideal bypass was studied in two groups of healthy albino rabbits. Both groups of rabbits were made hypercholesterolemic by feeding them cholesterol suspended in groundnut oil (1 ml/kg bw) at a dose of 100 ml/kg bw/day for one week. Group I rabbits were subjected to partial ileal bypass and group II rabbits were sham operated. Weekly estimation of serum lipid profiles were done for four more weeks while continuing cholesterol feed. After end of 5th week, it was found that partial ileal bypass not only prevented but also brought down its level from 132.8 mg% to 44.8 + 2.24 mg%, as compared to sham operates group where cholesterol level was 279 + 5.84 mg%. There was improvement in other parameters of lipid profiles namely HDL-C & LDL-C + VLDL-C and TAG.