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Related Experiment Videos

Multiple myeloma associated with lactic acidosis.

Celalettin Ustun1, Pamela Fall, Harold M Szerlip

  • 1Department of Internal Medicine, Medical College of Georgia, Veterans Affairs Medical Center, 1 Freedom Way, Augusta, GA 30904, USA.

Leukemia & Lymphoma
|March 5, 2003
PubMed
Summary

Type B lactic acidosis is a rare complication in patients with multiple myeloma (MM). This case report details a patient with refractory MM who experienced severe lactic acidosis during disease progression.

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Area of Science:

  • Oncology
  • Internal Medicine
  • Biochemistry

Background:

  • Type B lactic acidosis is infrequently associated with malignant diseases.
  • Multiple myeloma (MM) is a plasma cell malignancy with rare documented cases of lactic acidosis.

Observation:

  • A 55-year-old male diagnosed with stage IIIA immunoglobulin G-kappa (IgG-kappa) multiple myeloma presented with severe lactic acidosis.
  • The lactic acidosis occurred during the second relapse and terminal phase of his MM.
  • No alternative causes for the elevated lactate levels were identified.

Findings:

  • This case represents a rare instance of Type B lactic acidosis in a patient with multiple myeloma.
  • The patient required frequent hospitalizations for managing lactic acidosis and MM complications.

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  • Lactic acidosis may be a rare presenting or complicating factor in rapidly progressive and refractory MM.

    • Implications:

    • Highlights the potential for Type B lactic acidosis in advanced multiple myeloma.
    • Suggests that clinicians should consider lactic acidosis in refractory MM patients with unexplained metabolic acidosis.
    • Underscores the importance of recognizing rare metabolic complications in hematologic malignancies.