Related Experiment Video
Updated: Feb 22, 2026
07:38
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
836
Primary Indolent Acute Promyelocytic Leukemia
Breanne Wolfenbarger1, Daley Morera2, Brandol Wolfenbarger2
1Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA.
Hematology Reports
|February 20, 2026
Summary
This case report details an unusual, slow-progressing acute promyelocytic leukemia (APL) with specific genetic mutations. Early diagnosis and treatment led to remission, expanding the understanding of APL presentations.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Acute promyelocytic leukemia (APL) is an aggressive myeloid leukemia subtype.
- APL is defined by the PML::RARA fusion gene and often presents with severe coagulopathy.
- Prompt diagnosis and treatment are critical due to the disease's typically rapid progression.
Related Concept Videos
01:15Differentiation of Common Myeloid Progenitor Cells
4.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.1K
01:16Primary Lymphoid Organs
16.1K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.1K