Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thymic selection revisited: how essential is it?

Harald von Boehmer1, Iannis Aifantis, Fotini Gounari

  • 1Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. harald_von_boehmer@dfci.harvard.edu

Immunological Reviews
|March 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term renal benefit of a biopsy-guided personalized calcineurin inhibitor-sparing regimen late after liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
Same author

Integration of the naive pluripotency gene network with the response to GSK3 inhibition by Tcf7l1-driven enhancer decommissioning.

Stem cell reports·2026
Same author

Screening and care of patients with graft cirrhosis following liver transplantation.

Canadian liver journal·2026
Same author

Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases.

Communications medicine·2026
Same author

CLOCK is an Epigenetic Integrator of Circadian Rhythm and T Cell Immunity.

Research square·2026
Same author

Maternal obesity induces developmental programming of Intestinal stem cells through an IL-17A/PPAR immune-epithelial axis.

bioRxiv : the preprint server for biology·2026
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

T cell development in the thymus relies on Notch1 signaling for lineage commitment. Specific T cell receptors (TCRs) guide selection processes, ensuring immune tolerance and self-non-self discrimination for mammalian survival.

Area of Science:

  • Immunology
  • Developmental Biology

Background:

  • T cell development is a fundamental process in mammalian immunity.
  • The thymus is the primary site for T cell maturation.
  • Notch1 signaling is crucial for directing lymphoid precursors toward T cell lineages.

Purpose of the Study:

  • To elucidate the mechanisms of intrathymic T cell development.
  • To understand the roles of T cell receptors (TCRs) in lineage commitment.
  • To explore how the thymus achieves self-non-self discrimination.

Main Methods:

  • The study focuses on the molecular signaling pathways governing T cell differentiation.
  • It examines the function of Notch1 receptor and different TCRs (alphabetaTCR, gammadeltaTCR).
  • Selection processes (positive and negative) and their impact on T cell lineages are analyzed.

Related Experiment Videos

Main Results:

  • Notch1 receptor is essential for T cell lineage commitment.
  • The pre-TCR and gammadeltaTCR direct cells to distinct lineages (alphabeta and gammadelta, respectively).
  • Positive and negative selection refine the T cell repertoire, generating CD4+ and CD8+ T cells and preventing autoimmunity.

Conclusions:

  • Receptor-instructed lineage commitment and positive selection are key features of thymic T cell development.
  • The thymus ensures immune competence and self-tolerance through intricate selection mechanisms.
  • Ectopic expression of antigens aids in thymic self-non-self discrimination, vital for evolutionary fitness.