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Multiple symmetric lipomatosis: Korean experience.
Hae Wan Lee1, Tae Hwa Kim, Ji Woong Cho
1Department of General Surgery, College of Medicine, Hallym University, Chunchon, Korea. leehw@hallym.or.kr
Summary
Multiple symmetric lipomatosis (MSL) is a rare disorder characterized by abnormal fat growth. Surgical removal of fatty tissue and alcohol abstinence are crucial for improving quality of life in MSL patients.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Neurology
Background:
- Multiple symmetric lipomatosis (MSL) is a rare disorder causing abnormal adipose tissue growth, primarily in the neck, trunk, and limbs.
- A potential mechanism involves a defect in the fat cell's lipolytic pathway.
Purpose of the Study:
- To investigate the clinical, morphological, and biochemical characteristics of Korean patients with MSL.
- To identify associated metabolic and neurological abnormalities in MSL.
Main Methods:
- Retrospective analysis of 32 MSL patients (10 from the hospital, 22 from literature).
- Inclusion of biochemical analyses and neurological assessments.
- Evaluation of patient history, particularly alcohol consumption.
Main Results:
- All identified cases were sporadic MSL, with onset typically in middle age (mean 49.4 years) and a male predominance (31:1 ratio).
- A strong association with chronic alcoholism (over 80g/day for >10 years) was observed in most patients.
- Metabolic studies revealed hyperlipoproteinemia (Fredrickson type IIb or IV) in 3/17 patients, abnormal glucose tolerance in 5/17, and elevated HDL cholesterol in 3/17.
- Neurological abnormalities were prevalent, with peripheral neuropathy in 11/13 patients and central nervous system involvement in 3/13.
Conclusions:
- Surgical excision of excess adipose tissue and strict alcohol abstinence are vital for functional improvement in MSL.
- Comprehensive evaluation, including metabolic profiling for lipid abnormalities and thorough neurological examinations, is essential for enhancing patient quality of life.