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Peripheral retinal nonperfusion associated with chronic myeloid leukemia
Siamak Nobacht1, Kathleen F K Vandoninck, August F Deutman
1Department of Ophthalmology, University Medical Centre, Nijmegen, The Netherlands. s.nobacht@ohk.azn.nl
American Journal of Ophthalmology
|March 5, 2003
Summary
Peripheral retinal nonperfusion and neovascularization can be a complication of chronic myeloid leukemia (CML). This case highlights a unique presentation in a patient in remission, emphasizing the importance of comprehensive eye evaluations.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
- Ocular manifestations of CML can include retinal hemorrhages, exudates, and neovascularization.
Observation:
- A 23-year-old woman with a history of CML presented with bilateral peripheral retinal nonperfusion and neovascularization.
- Ophthalmic examination revealed extensive avascular retina with arteriovenous anastomosis and seafan neovascularizations.
- Blood work at diagnosis showed marked leukocytosis and thrombocytosis; the patient was in remission at the time of this report.
Findings:
- The patient exhibited peripheral retinal nonperfusion and neovascularization, specifically seafan neovascularizations.
- Unlike other reported cases, this patient had no signs of CML relapse, nor typical retinal findings like venous tortuosity or hemorrhages.
Implications:
- Peripheral retinal nonperfusion and neovascularization may be a distinct ocular complication of CML, even in remission.
- This case underscores the need for vigilant ophthalmic monitoring in CML patients.
- The unique presentation broadens the understanding of CML-associated retinopathy.