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Two stability-indicating UV spectrophotometric methods for the analysis of hydrolyzed tinidazole
Jukka-Pekka K Salo1, Hannele Salomies
1Division of Pharmaceutical Chemistry, Department of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FIN-00014 University of Helsinki, Helsinki, Finland. jpsalo@cc.helsinki.fi
Journal of Pharmaceutical and Biomedical Analysis
|March 5, 2003
Abstract:
Two UV spectrophotometric methods have been validated for the analysis of hydrolyzed tinidazole solutions. The pH of the samples must be 5.00-7.00 for both methods. The multiwavelength method may be used for samples degraded at pH 6-12 if the amount of conserved 5-nitroimidazole species is at least 93 mol.% of the original; the amounts of tinidazole and its two known impurities may be determined simultaneously. The accuracy was within 100+/-8% and the repeatability of measurement was