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Updated: Sep 27, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
Published on: March 2, 2018
Brain development and the genetics of brain development
1Departments of Pediatrics, Neurology, and Neuroscience, Cain Foundation Laboratories, 6621 Fannin Street, MC 3-6365, Houston, TX 77030-2399, USA. gclark@bcm.tmc.edu
Abstract:
The progress made in the understanding of the genetics of human brain malformations has lead to insight into the formation of brain and into mechanisms of disease affecting brain. It bears upon neurologists and geneticists to recognize the patterns of diseases of brain formation, to properly diagnose such disorders, to assess the recurrence risk of these malformations, and to guide families with appropriate expectations for outcomes. This article may serve as a guide to neurologists in their approach to these disorders. Because this area is one of rapid progress, the clinician is advised to seek more current information that may be available through on-line databases and other sources.
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