Congenital infections

James F Bale1

  • 1Division of Pediatric Neurology, University of Utah School of Medicine, Primary Children's Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113, USA. pcjbale@ihc.com

Neurologic Clinics
|March 6, 2003
PubMed

Insights

Intrauterine infections cause significant childhood disabilities like deafness and vision loss. This review covers pathogens, diagnosis, treatment, and prevention strategies for these infections.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Intrauterine infections are a major global cause of childhood sensorineural hearing loss, vision impairment, and neurodevelopmental disorders.
  • Despite advances like the rubella vaccine and congenital toxoplasmosis treatment, these infections remain a significant concern.

Purpose of the Study:

  • To review common pathogens responsible for intrauterine infections.
  • To summarize current diagnostic, therapeutic, and preventive measures for intrauterine infections.

Main Methods:

  • Literature review of common intrauterine pathogens.
  • Summary of current diagnostic modalities.
  • Overview of established treatment protocols.
  • Discussion of prevention strategies.

Main Results:

  • Identified key pathogens causing congenital infections.
  • Outlined current diagnostic approaches for timely detection.
  • Summarized effective treatment options for affected infants.
  • Highlighted the importance of preventive measures.

Conclusions:

  • Intrauterine infections continue to pose a substantial threat to child health worldwide.
  • Comprehensive understanding and application of diagnosis, treatment, and prevention are crucial.

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...