Optimising the therapeutic trinity of active ingredient, delivery system and functional packaging

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery
• Biopharmaceuticals

Background:

• Drug product formulation involves active ingredients, delivery systems, and packaging.
• Optimal therapeutic value requires a holistic approach to these components.

Purpose of the Study:

• Introduce the
• therapeutic trinity
• concept for drug product development.
• Highlight the importance of interdependent optimization of drug product components.
• Emphasize patient-centricity in drug development.

Main Methods:

• Conceptual framework development.
• Literature review on drug product components and patient factors.
• Analysis of efficacy, safety, quality, and cost parameters.

Main Results:

• The
• therapeutic trinity
• concept integrates active ingredient, delivery system, and packaging.
• Interdependent development and patient-focused optimization are crucial.
• Biopharmaceutical robustness and patient compliance are key determinants of success.

Conclusions:

• The
• therapeutic trinity
• framework guides the development of superior drug products.
• Integrating all components with the patient at the center maximizes therapeutic outcomes.
• Future drug development should prioritize this holistic, patient-centric approach.