Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Barbituates and biliary function.

J P Capron, S Erlinger

    Digestion
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Phenobarbital enhances bile flow and bilirubin clearance, aiding in treating certain liver conditions like unconjugated hyperbilirubinemia and gallstones. Its effects on biliary lipids vary by species.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.

    The American journal of gastroenterology·2017
    Same author

    [Portal hypertension caused by intra-hepatic block during chronic lymphoid leukemia].

    Gastroenterologie clinique et biologique·2003
    Same author

    [Diagnostic strategy when confronted with a moderate and prolonged increase of transaminases].

    Presse medicale (Paris, France : 1983)·2003
    Same author

    [Hepatic disorders related to Lyme disease. Study of two cases and a review of the literature].

    Gastroenterologie clinique et biologique·2001
    Same author

    [Epidemiology and natural history of cholelithiasis].

    La Revue du praticien·2001
    Same author

    Randomized trial of interferon-alpha plus ursodeoxycholic acid versus interferon plus placebo in patients with chronic hepatitis C resistant to interferon.

    Scandinavian journal of gastroenterology·2000
    Same journal

    Directional Bias in Polyp Detection during Colonoscopy: A Prospective Observational Study.

    Digestion·2026
    Same journal

    Prospective validation of magnified endoscopic examination with image-enhanced endoscopy as an optical biopsy for differentiating superficial duodenal epithelial tumor and non-neoplastic lesion in duodenum.

    Digestion·2026
    Same journal

    Accurate imaging diagnosis of small pancreatic carcinoma/high-grade pancreatic intraepithelial neoplasia using combined indirect imaging findings.

    Digestion·2026
    Same journal

    Restoration of gut microbiota dysbiosis by a probiotic Lactobacillus paragasseri OLL2716 in patients being treated with low-dose aspirin and acid-suppressive agents.

    Digestion·2026
    Same journal

    Adverse Events after Colorectal Polypectomy in Patients with Amyloidosis: Risk Assessment Using Propensity Score Matching.

    Digestion·2026
    Same journal

    Prognostic effect of MES 1 inflammatory extent on remission maintenance in ulcerative colitis.

    Digestion·2026
    See all related articles

    Area of Science:

    • Hepatology
    • Pharmacology
    • Gastroenterology

    Background:

    • Phenobarbital is a barbiturate with known effects on liver function.
    • Biliary function plays a crucial role in digestion and detoxification.
    • Understanding drug effects on biliary physiology is vital for therapeutic applications.

    Purpose of the Study:

    • To review the principal effects of phenobarbital on biliary function.
    • To elucidate the mechanisms underlying phenobarbital-induced choleresis.
    • To explore the therapeutic implications of phenobarbital's actions on bile flow and bilirubin metabolism.

    Main Methods:

    • Review of existing literature on phenobarbital's impact on biliary physiology.
    • Analysis of studies investigating bile flow, bile salt excretion, and dye clearance.

    Related Experiment Videos

  • Examination of phenobarbital's effects on hepatic enzymes and biliary lipids across species.

    • Main Results:

    • Phenobarbital increases bile flow, primarily via the bile salt-independent fraction, potentially linked to Na+-K+ ATPase activity.
    • It enhances the liver's uptake, storage, and excretion of dyes like sulfobromophthalein and increases bilirubin clearance.
    • Effects on biliary lipid composition, particularly cholesterol, differ significantly across species.

    Conclusions:

    • Phenobarbital's choleretic effects appear independent of microsomal enzyme induction.
    • The drug has demonstrated utility in treating chronic unconjugated hyperbilirubinemia, cholestatic syndromes, and cholesterol gallstones.
    • Further research is needed to clarify the relationship between phenobarbital's effect on bilirubin clearance and UDP-glucuronyl transferase activity.