Related Experiment Video
Updated: Aug 29, 2026
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Risk of Extra-Intestinal Solid Organ Malignancy in Patients with Inflammatory Bowel Disease: A Propensity-Matched
Background:
There is limited and conflicting data regarding the risk of thyroid, kidney and prostate cancer in patients with inflammatory bowel disease (IBD).
Methods:
This was a retrospective cohort study using the U.S. Collaborative Network comparing the risk of thyroid, kidney and prostate cancer in the IBD compared to non-IBD (control) cohort. One-to-one propensity score matching (PSM) was performed for demographics and co-morbid conditions. Cox proportional hazard model was used to identify risk factors for each cancer.
Results:
There were 200,280 matched pairs in the IBD and control cohort (mean age 43.7 +/- 19.5, 46.1% male, 76% White). There was an increased risk of thyroid (aOR 1.37, 95% CI 1.19-1.59), kidney (aOR 1.37, 95% CI 1.22-1.54) and prostate (aOR 1.39, 95% CI 1.29-1.151) cancer in the IBD compared to the control cohort. This was consistent based on IBD sub-type and sex. Racial/ethnic disparities were observed with respect to risk of each cancer. IBD cohort aged 18-39 was associated with increased risk (aOR 1.41, 95% CI 1.08-1.84) of thyroid but not kidney or prostate cancer compared to control cohort. Long-term steroid use was associated with an increased risk of thyroid (HR 1.92, 95% CI 1.15-3.20) and kidney (HR 1.52, 95% CI 1.25-1.86) cancer. T2DM and obesity were associated with an increased risk of all three cancers in the IBD cohort.
Conclusion:
We observed an increased risk of extra-intestinal solid organ malignancy, specifically thyroid, kidney and prostate cancer in patients with IBD.
Related Concept Videos
01:25Inflammatory Bowel Disease III: Crohn's Disease
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:26Inflammatory Bowel Disease I: Introduction
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations