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Virus-induced asthma.

A Bianco1, G Mazzarella, M Bresciani

  • 1Dipartimento di Scienze Cardio-Toraciche e Respiratorie, Seconda Università degli Studi di Napoli, c/o Hospital V. Monaldi, Via L. Bianchi, 80131 Naples, Italy. biancoan@hotmail.com

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|March 7, 2003
PubMed
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Respiratory viral infections, particularly Human Rhinovirus (HRV), are major triggers for asthma attacks in children and adults. While viruses clearly exacerbate asthma, their role in the initial development of the condition remains uncertain.

Area of Science:

  • Pediatric and adult respiratory medicine
  • Immunology
  • Epidemiology

Background:

  • Respiratory viral infections are significant triggers for asthma exacerbations.
  • Human Rhinovirus (HRV) is the most frequently identified virus linked to asthma episodes.
  • Viral infections in early life may influence lung development and immune responses, potentially contributing to asthma inception.

Purpose of the Study:

  • To review the evidence linking viral infections to asthma exacerbations.
  • To explore the potential role of viral infections in the development of asthma.
  • To clarify the association between respiratory viruses and asthma pathogenesis.

Main Methods:

  • Review of clinical and experimental investigations.
  • Analysis of epidemiological data on asthma exacerbations.

Related Experiment Videos

  • Examination of the impact of early-life viral infections on lung and immune development.

    • Main Results:

    • Viral upper respiratory infections account for 80% of childhood asthma exacerbations and 50% of adult asthma episodes.
    • HRV is consistently implicated as a primary viral cause of asthma exacerbations.
    • Evidence suggests viruses may act as co-factors in asthma development by altering lung or immune system maturation.

    Conclusions:

    • Viruses are definitively established as critical factors in asthma exacerbations.
    • The role of viral infections in the primary development or inception of asthma is still a subject of ongoing research and debate.