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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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H2S-Scavenging Hydrogel Alleviating Mitochondria Damage to Control Periodontitis.

C Xie1,2, Q Zhang1,2, A Bianco3

  • 1Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, China.

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Summary

This study developed a novel hydrogel that effectively scavenges hydrogen sulfide (H₂S), a key factor in periodontitis. This H₂S-scavenging hydrogel promotes periodontal tissue regeneration and enhances treatment efficacy.

Keywords:
bacteriabiocompatible materialsbone remodelinginfection controlinflammation

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Area of Science:

  • Biomaterials Science
  • Periodontology
  • Regenerative Medicine

Background:

  • Hydrogen sulfide (H₂S) is a metabolite of periodontal pathogens, correlating positively with periodontitis.
  • Excess H₂S in periodontal pockets exacerbates inflammation, oxidative stress, mitochondrial damage, and bacterial proliferation, hindering periodontitis treatment.
  • Current periodontitis treatments often overlook the crucial role of H₂S scavenging.

Purpose of the Study:

  • To develop an H₂S-scavenging composite hydrogel for enhanced periodontitis therapy.
  • To investigate the efficacy of the hyaluronic acid methacryloyl/ZnO (HMZ) hydrogel in mitigating H₂S-induced damage and promoting periodontal regeneration.

Main Methods:

  • Fabrication of a hyaluronic acid methacryloyl/ZnO (HMZ) composite hydrogel with H₂S-scavenging capabilities.
  • In vitro assessment of HMZ hydrogel's cytocompatibility, H₂S removal efficiency, and effects on human gingival and periodontal ligament fibroblasts.
  • In vivo evaluation of HMZ hydrogel's therapeutic effects on periodontitis, including H₂S reduction, bacterial clearance, inflammation control, and bone regeneration.

Main Results:

  • The HMZ hydrogel demonstrated good injectability and cytocompatibility, effectively scavenging H₂S.
  • In vitro studies showed HMZ hydrogel significantly improved fibroblast viability, restored mitochondrial homeostasis, and alleviated inflammation.
  • In vivo results indicated HMZ hydrogel reduced periodontal H₂S levels, eliminated bacteria, inhibited osteoclast activity, reduced inflammation, and promoted significant periodontal bone regeneration.

Conclusions:

  • The developed HMZ hydrogel presents a promising H₂S-scavenging strategy to enhance periodontitis treatment outcomes.
  • This approach effectively addresses H₂S-mediated pathological processes, leading to improved periodontal tissue health and regeneration.
  • The HMZ hydrogel offers a novel therapeutic avenue for periodontitis by targeting a key etiological factor.