Related Experiment Video
Updated: Aug 6, 2026
08:55
Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
Published on: July 6, 2022
A Bioactive Janus Barrier Membrane Rejuvenates Bone Regeneration in Aging
1Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Disease & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China.
Journal of Dental Research
|July 25, 2026
Summary
This study developed a novel Janus barrier membrane to improve bone regeneration in aging individuals. The QSHP membrane enhanced stem cell function and bone healing, offering a promising clinical strategy for aged patients.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Gerontology
Background:
- Aging impairs guided bone regeneration (GBR) by reducing stem cell function and increasing cellular senescence.
- Current GBR strategies are less effective in aged populations due to these age-related changes.
Purpose of the Study:
- To engineer a novel Janus barrier membrane (QSHP) for enhanced GBR in aged individuals.
- To investigate the in vitro and in vivo efficacy of the QSHP membrane in rejuvenating the bone regenerative niche.
Main Methods:
- Fabrication of a quercetin and Sr-hydroxyapatite/poly(lactic-co-glycolic acid) (QSHP) Janus membrane with asymmetric layers.
- In vitro assessment of stem cell migration, proliferation, senescence, and osteogenic capacity.
- In vivo evaluation in aged rat mandibular defects, analyzing bone volume, biomechanics, and cellular markers.
Main Results:
- The QSHP membrane promoted bone marrow mesenchymal stem cell migration and proliferation while reducing senescence.
- In aged rats, QSHP treatment significantly increased newly formed bone volume and restored biomechanical properties.
- Histological analysis showed accelerated osteogenesis, enhanced CD44+ stem cell recruitment, and reduced senescence.
Conclusions:
- The QSHP Janus membrane effectively rejuvenates the aged bone regenerative environment.
- This biomaterial offers a promising therapeutic strategy for improving GBR outcomes in elderly patients.
Keywords:
agedcellular senescencepolylactic acid–polyglycolic acid copolymerquercetinstem cellsstrontiumMore Related Videos
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