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Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.

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Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films
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Dual-Network Silk Fibroin/Quercetin Hydrogel for Periodontitis Treatment.

H Zhang1, X Mao1, S Ge1

  • 1Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China.

Journal of Dental Research
|March 9, 2026
PubMed
Summary

A novel silk fibroin/quercetin hydrogel effectively treats periodontitis by fighting infection, reducing inflammation, and balancing the immune response. This injectable material promotes tissue repair and offers a promising therapeutic strategy.

Keywords:
bioactive materialscell biologyimmunityinfection controlinflammationscaffolds

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Area of Science:

  • Biomaterials Science
  • Periodontology
  • Immunology

Background:

  • Periodontitis involves bacterial infection, oxidative stress, inflammation, and immune dysregulation.
  • Current treatments require strategies addressing multiple pathological factors simultaneously.

Purpose of the Study:

  • To develop an injectable silk fibroin/quercetin (SFQ) hydrogel for periodontitis management.
  • To evaluate the SFQ hydrogel's efficacy in combating infection, oxidative stress, inflammation, and immune imbalance.

Main Methods:

  • Self-assembly of silk fibroin and quercetin to form a dual-network hydrogel.
  • In vitro assessment of biocompatibility, ROS scavenging, anti-inflammatory, and antibacterial properties.
  • In vivo evaluation of therapeutic effects on periodontitis models.

Main Results:

  • SFQ hydrogel demonstrated high biocompatibility, promoted cell migration, scavenged ROS, and protected cells from apoptosis.
  • The hydrogel exhibited significant anti-inflammatory effects, modulated macrophage polarization (M1 to M2), and inhibited bacterial growth and biofilm formation.
  • In vivo studies showed SFQ hydrogel effectively reduced inflammation, collagen destruction, and promoted immune regulation for tissue remodeling.

Conclusions:

  • The self-assembled SFQ hydrogel is a promising therapeutic agent for periodontitis.
  • SFQ hydrogel offers a multi-faceted approach to periodontitis treatment by addressing key pathological mechanisms.