Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions

Progesterone from ovulatory menstrual cycles is an important cause of breast cancer.

Breast cancer research : BCR·2023

Estrogen for the Treatment and Prevention of Breast Cancer: A Tale of 2 Karnofsky Lectures.

Cancer journal (Sudbury, Mass.)·2022

Serendipity in the search for "morning-after pills" led to clomiphene for the induction of ovulation.

F&S science·2022

Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer.

Frontiers in endocrinology·2022

Estrogen Receptor and the Unfolded Protein Response: Double-Edged Swords in Therapy for Estrogen Receptor-Positive Breast Cancer.

Targeted oncology·2022

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer.

Molecular cancer research : MCR·2021

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids.

Journal of medicinal chemistry·2026

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody-Oligonucleotide Conjugates with High Drug-to-Antibody Ratios.

Journal of medicinal chemistry·2026

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Journal of medicinal chemistry·2026

Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.

Journal of medicinal chemistry·2026

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.

Journal of medicinal chemistry·2026

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Journal of medicinal chemistry·2026

Sedative-hypnotic properties and mitochondrial effects of coenzyme Q2 in mice.

Current molecular pharmacology·2026

Trends in Medicines Discontinuation and Implications for Access in Brazil (2014-2024).

Pharmacoepidemiology and drug safety·2026

Carabrone alleviates neuroinflammation by covalently targeting ubiquitin conjugating enzyme UBE2D3 in experimental autoimmune encephalomyelitis.

European journal of pharmacology·2026

The natural coumarin 7-methoxy-8-isopentenyloxycoumarin alleviates LPS-induced inflammation by suppressing NF-κB and the MAPK/AP-1 pathways and accelerating COX-2 proteasomal degradation.

European journal of pharmacology·2026

Emergency department diagnosis and management of acetaminophen or salicylate toxicity.

Emergency medicine practice·2026

Reduced Codeine Analgesic Efficacy Associated with Nicardipine in a Patient with Medication-Overuse Headache: A Case Report.

Journal of pain & palliative care pharmacotherapy·2026

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Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions

Related Concept Videos

Progesterone from ovulatory menstrual cycles is an important cause of breast cancer.

Estrogen for the Treatment and Prevention of Breast Cancer: A Tale of 2 Karnofsky Lectures.

Serendipity in the search for "morning-after pills" led to clomiphene for the induction of ovulation.

Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer.

Estrogen Receptor and the Unfolded Protein Response: Double-Edged Swords in Therapy for Estrogen Receptor-Positive Breast Cancer.

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer.

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids.

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody-Oligonucleotide Conjugates with High Drug-to-Antibody Ratios.

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Sedative-hypnotic properties and mitochondrial effects of coenzyme Q2 in mice.

Trends in Medicines Discontinuation and Implications for Access in Brazil (2014-2024).

Carabrone alleviates neuroinflammation by covalently targeting ubiquitin conjugating enzyme UBE2D3 in experimental autoimmune encephalomyelitis.

The natural coumarin 7-methoxy-8-isopentenyloxycoumarin alleviates LPS-induced inflammation by suppressing NF-κB and the MAPK/AP-1 pathways and accelerating COX-2 proteasomal degradation.

Emergency department diagnosis and management of acetaminophen or salicylate toxicity.

Reduced Codeine Analgesic Efficacy Associated with Nicardipine in a Patient with Medication-Overuse Headache: A Case Report.

Related Experiment Videos

Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions

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