Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plant defense: one post, multiple guards?!

Rajendra Marathe1, S P Dinesh-Kumar

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Molecular Cell
|March 7, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formulation Optimization and Characterization of Tizanidine Hydrochloride-loaded Gold Nanoparticles Using Quality by Design Approach.

Pharmaceutical nanotechnology·2024
Same author

Combination of mTOR and MAPK Inhibitors-A Potential Way to Treat Renal Cell Carcinoma.

Medical sciences (Basel, Switzerland)·2017
Same author

Plasma Hepcidin Levels in Healthy Children from Chandigarh, Northern India.

Indian pediatrics·2017
Same author

Arabidopsis ATG4 cysteine proteases specificity toward ATG8 substrates.

Autophagy·2014
Same author

Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases.

Proceedings of the National Academy of Sciences of the United States of America·2014
Same author

Sulphonamido-quinoxalines: search for anticancer agent.

European journal of medicinal chemistry·2013

Arabidopsis RIN4 protein is a target for bacterial pathogens. Resistance proteins RPM1 and RPS2 detect modifications to RIN4, initiating plant defenses against bacterial virulence.

Area of Science:

  • Plant immunology
  • Molecular plant-pathology
  • Plant-microbe interactions

Background:

  • RIN4 is a crucial target protein for bacterial pathogens in Arabidopsis.
  • Resistance (R) proteins RPM1 and RPS2 are known to guard RIN4.
  • Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 modify RIN4.

Purpose of the Study:

  • To investigate the role of R proteins RPM1 and RPS2 in guarding the Arabidopsis RIN4 protein.
  • To understand how bacterial Avr effectors target RIN4 and trigger plant immune responses.

Main Methods:

  • Analysis of plant-RPS2-RIN4 interactions.
  • Bacterial effector protein expression and functional assays.
  • Plant defense signaling pathway activation studies.

Related Experiment Videos

Main Results:

  • Evidence supporting RPS2 as a RIN4 guard, alongside RPM1.
  • Demonstration that AvrB, AvrRpm1, and AvrRpt2 effectors alter RIN4.
  • RPM1 and RPS2 recognize RIN4 alterations to activate defense.

Conclusions:

  • RIN4 is guarded by multiple R proteins, including RPM1 and RPS2.
  • Bacterial effectors manipulate RIN4 to evade or suppress plant immunity.
  • The guard hypothesis provides a framework for understanding plant R protein function.