Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Histopathologic correlation in dermoscopy: a micropunch technique.

Ralph Peter Braun¹, Gürkan Kaya, Isabelle Masouyé

¹Pigmented Skin Lesion Clinic, Department of Dermatology, University Hospital Geneva, 24, rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. braun@melanoma.ch

Archives of Dermatology

|March 8, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editor's Note: Myc-Transformed Epithelial Cells Down-Regulate Clusterin, Which Inhibits Their Growth in Vitro and Carcinogenesis in Vivo.

Cancer research·2026

Same author

Specific In Vivo Ablation of Lrig1-Positive Follicular Progenitor Cells Results in Sebaceous Gland Loss in Mice.

International journal of molecular sciences·2026

Same author

Increased Expression of Angiopoietin 2 and Tie2 in Rosacea.

Dermatopathology (Basel, Switzerland)·2026

Same author

Big Bang in Face Care: How to Maintain Skin Cell Homeostasis in Rosacea and Acne.

Dermatology (Basel, Switzerland)·2025

Same author

Asymmetric Lip Hyperpigmentation in a Transplant Patient.

Dermatopathology (Basel, Switzerland)·2025

Same author

The 'mono-side' of cutaneous adverse drug reactions.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025

A novel micropunch technique enables direct visual correlation between dermoscopy and histopathology for pigmented skin lesions. This method enhances diagnostic accuracy by precisely linking in vivo imaging with tissue analysis.

Area of Science:

Dermatology
Pathology
Medical Imaging

Background:

Dermoscopy is a valuable in vivo diagnostic tool for pigmented skin lesions, including malignant melanoma.
Accurate correlation between dermoscopic and histopathologic findings is crucial for diagnosis.
Existing methods lack direct visual correlation, hindering precise anatomical linking.

Purpose of the Study:

To introduce and validate a new micropunch technique for direct visual correlation of dermoscopic and histopathologic findings.
To improve the accuracy of diagnosing pigmented skin lesions by bridging in vivo imaging and ex vivo tissue analysis.

Main Methods:

A 1-mm micropunch creates a superficial incision in the lesion of interest under local anesthesia.
Digital dermoscopy images are captured before and after the punch procedure.

Related Experiment Videos

The punch site serves as a precise landmark for correlating dermoscopic images with subsequent histopathologic sections.

Main Results:

The micropunch technique allows laboratory technicians to easily identify the exact site of interest from dermoscopic images.
Histopathologic sections can be precisely oriented to pass through the punch incision, ensuring accurate anatomical correlation.
The technique does not interfere with critical histopathologic measurements, such as Breslow thickness.

Conclusions:

The micropunch technique is simple, requires minimal training, and can be performed in various clinical settings, including private practice.
It eliminates the need for the clinician's presence during histopathologic sectioning.
This method establishes the first direct visual correlation between dermoscopy and histopathology, empowering clinicians to guide pathologists to specific areas of concern.