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Related Experiment Videos

Cortical bone resorption during exercise is interleukin-6 genotype-dependent.

Sukhbir S Dhamrait1, Laurence James, David J Brull

  • 1Department of Cardiovascular Genetics, BHF Laboratories at UCL, Rayne Building, Royal Free and University College Medical School, 5 University Street, London, UK.

European Journal of Applied Physiology
|March 11, 2003
PubMed
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The interleukin-6 (IL-6) -174 G>C gene variant influences bone changes during intense exercise. Specific IL-6 genotypes affected femoral bone loss or gain in army recruits undergoing physical training.

Area of Science:

  • Bone biology and genetics
  • Exercise physiology
  • Human skeletal adaptation

Background:

  • Interleukin-6 (IL-6) is implicated in bone mass regulation, particularly in postmenopausal women and metastatic bone disease.
  • The role of IL-6 in bone remodeling in healthy young males during physical stress is less understood.

Purpose of the Study:

  • To investigate the association between the interleukin-6 (IL-6) -174 G>C promoter polymorphism and exercise-induced changes in femoral cortical bone.
  • To determine if IL-6 genotype influences skeletal response to strenuous physical training.

Main Methods:

  • 130 male army recruits underwent a 10-week physical training program.
  • Femoral cortical bone area was measured using magnetic resonance imaging before and after training.
  • Recruits were genotyped for the IL-6 -174 G>C promoter polymorphism.

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Main Results:

  • Significant differences in femoral cortical area changes were observed based on IL-6 genotype (P=0.007).
  • GG homozygotes experienced a decrease in cortical area, while GC and CC genotypes showed increases.
  • These genotype-dependent bone remodeling effects were significant throughout the femur.

Conclusions:

  • A functional polymorphism in the IL-6 gene is associated with femoral cortical bone remodeling during strenuous exercise.
  • These findings support a fundamental role for IL-6 in regulating bone mass and remodeling in humans across different contexts.
  • The study extends previous observations on IL-6's role in bone to healthy males undergoing physical stress.