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Carbonated calcium phosphates are suitable pH-stabilising fillers for biodegradable polyesters
Carsten Schiller1, Matthias Epple
1Solid State Chemistry, Faculty of Chemistry, University of Bochum, Universitaetsstr. 150, D-44780, Bochum, Germany.
Biomaterials
|March 12, 2003
Summary
Carbonated calcium phosphates effectively neutralize acidity and buffer within the physiological pH range, making them ideal for use as basic filler materials. This study investigated their acid-neutralizing capacity for potential applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biomineralization
Background:
- Polylactide (PLA) degradation produces lactic acid, which can lower the pH.
- Biomaterials require buffering capacity to maintain physiological pH.
- Calcium phosphates are common biomaterials, but their inherent buffering properties need evaluation.
Purpose of the Study:
- To prepare carbonated amorphous calcium phosphates with varying carbonate content.
- To evaluate the acid-neutralizing and buffering capabilities of these materials.
- To determine their suitability as basic filler materials for biomedical applications.
Main Methods:
- Synthesis of carbonated amorphous calcium phosphates with controlled carbonate content.
- Time-resolved titration experiments using lactic acid.
- pH monitoring to assess buffering capacity within the physiological range.
Main Results:
- Uncarbonated calcium phosphate buffers at pH ~4, outside the physiological range.
- Carbonated calcium phosphates and calcium carbonate (calcite) effectively buffer around pH 7.4.
- Buffering capacity is not limited by the rate of dissolution.
Conclusions:
- Carbonated calcium phosphates exhibit significant acid-neutralizing properties.
- These materials are suitable for buffering within the physiological pH range.
- Carbonated calcium phosphates are promising candidates as basic filler materials in biomedical applications.