Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Airway remodeling in asthma.

Antonio M Vignola1, Franco Mirabella, Giorgio Costanzo

  • 1Istituto di Medicina Generale e Pneumologia, Università di Palermo, Palermo, Italy. vignola.am@iol.it

Chest
|March 12, 2003
PubMed
Summary

Chronic inflammation and airway remodeling in asthma involve cellular infiltration, tissue proliferation, and structural changes. Understanding these processes is crucial for managing asthma long-term.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adipokines in Obese Asthma: A Complex Relationship Influenced More by Sex, Weight, and Oral Steroid Treatment Than Disease Severity.

Allergy·2026
Same author

The Interplay Between Oxidant/Antioxidant System, Transcription Factors, and Non-Coding RNA in Lung Cancer.

International journal of molecular sciences·2025
Same author

IL-17A Drives Oxidative Stress and Cell Growth in A549 Lung Epithelial Cells: Potential Protective Action of Oleuropein.

Nutrients·2024
Same author

Retraction notice to "Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients" [Immunobiology 219(5) (2014) 392-401].

Immunobiology·2024
Same author

Retraction notice to "In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD" [Immunobiology 217/3 (2012) 345-353].

Immunobiology·2024
Same author

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.

The European respiratory journal·2021

Area of Science:

  • Pathology
  • Pulmonology
  • Immunology

Background:

  • Chronic inflammation and remodeling are key features of asthma.
  • Structural changes in the airway wall significantly impact lung function and reactivity.
  • Asthma remodeling, characterized by collagen deposition, is often present but not always clinically evident.

Purpose of the Study:

  • To investigate the contribution of structural changes to altered airway function in asthma.
  • To highlight the importance of airway remodeling in the long-term prognosis of asthma.
  • To identify knowledge gaps in understanding asthma pathology and its clinical manifestations.

Main Methods:

  • Histologic examination of biopsy specimens to identify hallmarks of chronic inflammation and remodeling.

Related Experiment Videos

  • Analysis of physiological parameters such as FEV(1) and bronchial hyperresponsiveness.
  • Review of existing literature to identify gaps in knowledge regarding airway remodeling in asthma.

    • Main Results:

    • Histologic hallmarks include macrophage/lymphocyte infiltration, fibroblast proliferation, angiogenesis, fibrosis, and tissue destruction.
    • Airway remodeling is consistently found in asthma biopsy specimens.
    • Airway remodeling contributes to irreversible airflow obstruction, accelerated FEV(1) decline, and bronchial hyperresponsiveness, particularly in severe asthma.

    Conclusions:

    • Airway remodeling is a critical factor in asthma's long-term course, even after anti-inflammatory treatment.
    • There are significant gaps in understanding the precise correlation between structural pathology and physiological changes in asthma.
    • Further long-term studies and research into methods for limiting airway remodeling are essential for improved asthma management.