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[Gardner syndrome. Case reports].

Ferenc Koppány1, Arpád Joób-Fancsaly, Levente Pataky

  • 1Semmelweis Orvostudományi Egyetem, Szájsebészeti és Fogászati Klinika.

Fogorvosi Szemle
|March 13, 2003
PubMed
Summary

Gardner syndrome involves intestinal polyposis, osteomas, and skin tumors. Early dental or mandibular lesions can indicate this condition, prompting investigation for malignant polyposis.

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Area of Science:

  • Medical Genetics
  • Oncology
  • Dentistry

Background:

  • Gardner syndrome is an inherited disorder characterized by familial adenomatous polyposis (FAP).
  • It presents with extracolonic manifestations including osteomas and skin tumors.
  • Early diagnosis is crucial due to the high risk of colorectal cancer.

Observation:

  • This report details three cases of Gardner syndrome.
  • Key features observed were malignant large intestine polyposis, multiple osteomas, and various skin tumors.
  • Dental and/or mandibular lesions were noted as the earliest presenting symptoms.

Findings:

  • The study highlights the diagnostic significance of dental and mandibular abnormalities in suspecting Gardner syndrome.
  • Malignant polyposis of the large intestine is a primary concern in affected individuals.

Related Experiment Videos

  • The combination of polyposis, osteomas, and skin tumors defines the syndrome's presentation.
  • Implications:

    • Recognizing early dental signs can lead to timely diagnosis of Gardner syndrome.
    • Prompt identification facilitates management of colorectal cancer risk.
    • This underscores the interdisciplinary approach needed for managing rare genetic syndromes.