Related Experiment Videos
Osteogenesis by guided tissue regeneration and demineralized bone matrix
N Mardas1, L Kostopoulos, A Stavropoulos
1Department of Periodontology and Oral Gerontology, Royal Dental College, University of Aarhus, Denmark.
Journal of Clinical Periodontology
|March 13, 2003
Summary
Demineralized bone matrix (DBM) did not enhance bone formation during guided tissue regeneration (GTR) in rats. However, DBM did increase the density of newly formed bone at 120 days.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oral and Maxillofacial Surgery
Background:
- Guided tissue regeneration (GTR) is a technique used to regenerate lost periodontal tissues.
- Demineralized bone matrix (DBM) is a bone graft material that has been shown to promote bone formation.
Purpose of the Study:
- To evaluate the effect of DBM on bone formation in a GTR model.
- To determine if DBM enhances bone regeneration when used as an adjunct to GTR.
Main Methods:
- A rat mandibular ramus model was used to assess bone formation.
- Teflon capsules containing DBM were implanted, with empty capsules serving as controls.
- Histological analysis was performed at 15, 30, and 120 days to quantify bone formation.
Main Results:
- Bone fill increased in both DBM and control groups over time.
- At 30 days, control sites showed significantly more bone fill than DBM sites.
- At 120 days, no significant difference in bone fill was observed, but DBM sites had denser newly formed bone.
Conclusions:
- DBM did not enhance bone formation in this GTR model.
- DBM increased the density of newly formed bone.
- DBM may not be beneficial as an adjunct to GTR for increasing bone volume but may improve bone quality.