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1,2-cyclic sulfamidates as versatile precursors to thiomorpholines and piperazines
Andrew J Williams1, Suda Chakthong, Diane Gray
1School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
Organic Letters
|March 14, 2003
Abstract:
[reaction: see text] 1,2-Cyclic sulfamidates undergo regiospecific nucleophilic displacement with either methyl thioglycolate or alpha-amino esters, followed by lactamization (thermal, base-mediated, or cyanide-catalyzed), to give thiomorpholin-3-ones and piperazin-2-ones.