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Updated: Aug 11, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
Published on: January 6, 2014
T-cell responses of vaccinated cancer patients
Pierre G Coulie1, Pierre van der Bruggen
1Cellular Genetics Unit, Christian de Duve Institute of Cellular Pathology, Université de Louvain, Avenue Hippocrate 74, UCL 7459, B-1200 Brussels, Belgium. coulie@gece.ucl.ac.be
Abstract:
Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Several reports describe anti-vaccine T-cell responses, evaluated with a variety of methods, for example, by assessing T-cell function or expression of specific TCR. However, a correlation between these T-cell responses and the tumor regressions has not yet been established. It appears that some patients display tumor regression with an unexpectedly low frequency of anti-vaccine T cells.
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