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Related Experiment Videos

The human obesity gene map: the 2002 update.

Yvon C Chagnon1, Tuomo Rankinen, Eric E Snyder

  • 1Psychiatric Genetic Unit, Laval University Robert-Giffard Research Center, Beauport, Québec, Canada. Yvon.Chagnon@crulrg.ulaval.ca

Obesity Research
|March 14, 2003
PubMed
Summary

This ninth update maps over 300 genes and regions linked to human obesity. It incorporates new animal models and genetic studies, advancing our understanding of obesity genetics.

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Area of Science:

  • Genetics
  • Obesity Research
  • Genomics

Background:

  • The human obesity gene map is a critical resource for understanding the genetic basis of obesity.
  • Previous updates have cataloged genes and chromosomal regions associated with obesity phenotypes.

Purpose of the Study:

  • To provide the ninth update of the human obesity gene map, incorporating data through October 2002.
  • To consolidate evidence from various genetic studies, including Mendelian disorders, quantitative trait loci (QTLs), and candidate gene associations.
  • To include novel data from transgenic and knockout murine models of obesity.

Main Methods:

  • Systematic review of published literature up to October 2002.
  • Inclusion of data from single-gene mutations, Mendelian syndromes, human genome-wide scans, animal crossbreeding experiments, and candidate gene studies.

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  • Integration of data from transgenic and knockout mouse models.

    • Main Results:

    • 33 Mendelian syndromes relevant to obesity have been mapped, with causal genes identified for 23.
    • 168 animal QTLs and 68 human QTLs for obesity phenotypes have been reported.
    • Over 300 genes, markers, and chromosomal regions are now associated or linked with human obesity, found on all chromosomes except Y.
    • 222 studies report positive associations with 71 candidate genes, 15 of which are supported by at least five studies.
    • Seven genomic regions harbor replicated QTLs.
    • 38 transgenic and knockout murine models were incorporated.

    Conclusions:

    • The ninth update significantly expands the human obesity gene map, reflecting a growing body of genetic research.
    • The map highlights numerous genetic loci and candidate genes implicated in human obesity.
    • Continued research, including diverse genetic models, is crucial for unraveling the complex genetic architecture of obesity.