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Altered enzymes in ageing human fibroblasts

R Holliday1, G M Tarrant

  • 1National Institute for Medical Research, Mill Hill, London NW7 1AA.

Nature
|July 7, 1972
PubMed
Summary

Diploid human fibroblasts show heat-labile enzymes near the end of their lifespan. The compound 5-fluorouracil (5-FU) triggers early aging, supporting the "error catastrophe" theory of aging.

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