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Related Experiment Videos

Urinary plasma protein patterns in acute prostatitis.

Karel Everaert1, Joris Delanghe, Marc Vanderkelen

  • 1Department of Urology, Ghent University Hospital, Ghent, Belgium. karel.everaert@rug.ac.be

Clinical Chemistry and Laboratory Medicine
|March 15, 2003
PubMed
Summary

Urinary alpha2-macroglobulin levels can help diagnose acute prostatitis. Low levels, especially with hematuria, indicate this condition, distinguishing it from other urinary tract infections.

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Area of Science:

  • Urology
  • Clinical Chemistry
  • Biomarker Discovery

Background:

  • Acute prostatitis diagnosis can be challenging.
  • Novel urinary biomarkers are needed for accurate differentiation of urinary tract infections.

Purpose of the Study:

  • To evaluate the diagnostic utility of urinary alpha1-microglobulin, alpha2-macroglobulin, and albumin in diagnosing acute prostatitis.
  • To differentiate acute prostatitis from other urinary tract infections like cystitis and acute pyelonephritis.

Main Methods:

  • Studied 133 men with acute prostatitis and a reference population without urinary tract infection.
  • Analyzed urinary alpha1-microglobulin/creatinine and alpha2-macroglobulin/albumin ratios using immunonephelometry.
  • Utilized stepwise multinomial logistic regression for biomarker differentiation.

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Main Results:

  • The urinary alpha2-macroglobulin/albumin ratio was significantly lower in patients with acute prostatitis (p < 0.0001).
  • Low alpha2-macroglobulin is attributed to inhibition by soluble prostatic proteins in urine.
  • Urinary alpha1-microglobulin/creatinine ratio diagnosed acute pyelonephritis (100% sensitivity, 87% specificity).
  • Urinary alpha2-macroglobulin/albumin ratio diagnosed acute prostatitis (100% sensitivity, 90% specificity).
  • Combined biomarkers optimally differentiated between acute pyelonephritis and acute prostatitis (pseudo R2=0.83).

Conclusions:

  • The combination of hematuria and absence of urinary alpha-2-macroglobulin is diagnostic for acute prostatitis.
  • Urinary alpha2-macroglobulin levels remain lower in prostatitis even without hematuria, aiding diagnosis.