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A case of incomplete postganglionic cholinergic dysautonomia
Dong Wook Kim1, Kyung-Il Park, Keun-Hwa Jung
1Department of Neurology, Seoul National University Hospital, Seoul, Korea.
Journal of Neurology
|March 15, 2003
Summary
Postganglionic cholinergic dysautonomia, a rare nervous system disorder, can cause bladder issues. This case suggests tonic pupil and dysautonomia may share underlying causes, differing mainly in severity.
Area of Science:
- Neurology
- Autonomic Nervous System Disorders
Background:
- Postganglionic cholinergic dysautonomia is an uncommon condition affecting the parasympathetic and sympathetic nervous systems.
- It typically manifests as acute, selective dysfunction, impacting functions like sweating.
Observation:
- A 27-year-old woman presented with subacute onset of bladder paresis.
- Clinical findings indicated selective parasympathetic nervous system dysfunction, including mydriasis (dilated pupils) and diminished tearing.
- The sympathetic sudomotor system function remained unaffected.
Findings:
- The patient was diagnosed with incomplete postganglionic cholinergic dysautonomia.
- Evidence suggests a potential shared pathogenesis between tonic pupil and postganglionic cholinergic dysautonomia.
- Disease manifestation may vary based on severity and extent.
Implications:
- This case highlights the spectrum of cholinergic dysautonomia.
- It suggests unifying the understanding of tonic pupil and dysautonomia under a common pathophysiological framework.
- Further research into shared mechanisms could improve diagnostic and therapeutic strategies for autonomic dysfunction.