[Platelet adhesion and antioxidant therapy in experimental stress]

We have investigated the platelet activity, by platelet adhesion index and the end products of lipid peroxidation--MDA. Platelet adhesion index was established using Rovatti's method. Determinations were carried out on experimental model consisting of five groups of white male Wistar rats. In the vitamin E supplemented group, the platelet adhesion index was constantly correlated with MDA level. Thus there is a correlation between the intensity of the oxidative stress and vitamin E supplementation. The imbalance between pro- and antioxdants in experimental stress may enhance the platelet adhesion via arachidonic acid metabolism and endoperoxides formation. Steady administration of vitamin E in the experimental stress, due to its antioxidant properties, causes the progressive decrease of peroxidation and of platelet adhesion.